High affinity uptake of neurotransmitter amino acids
نویسندگان
چکیده
منابع مشابه
High-affinity uptake of L-kynurenine by a Na+-independent transporter of neutral amino acids in astrocytes.
L-Kynurenine (KYN), an intermediary product in the kynurenine pathway of tryptophan metabolism, is the common precursor from which are formed both quinolinic acid, a potent endogenous "excitotoxin," and kynurenic acid, a nonselective antagonist of excitotoxins. The present work examines 3H-KYN transport in primary astrocyte cultures derived from the cerebra of newborn mice. Influx and efflux of...
متن کاملHigh-affinity analogues of neuropeptide Y containing conformationally restricted non-proteinogenic amino acids.
High-afnnity analogues of neuropeptide Y containing conformationally restricted non-proteinogenic amino acids Annette G. Beck-Sickinger*t, Eike Hoffmann*, Klaus Padinit, Hans-Ulrich Reissigt, Klaus-Dieter WillimQ, Heike A. WielandQ and Gunther Jung* *Institute of Organic Chemistry, University of Tubingen, Auf der Morgenstelle 18, D-72076 Tubingen, Germany, $Institute of Organic Chemistry, Techn...
متن کاملDeciphering the specific high-affinity binding of cucurbit[7]uril to amino acids in water.
This work presents a systematic study on the host-guest interactions between the macrocyclic host molecule cucurbit[7]uril (CB[7]) and amino acids (AAs) including three basic AAs (Lys, Arg, and His) and three aromatic AAs (Phe, Tyr, and Trp) to elucidate the origin of the high selectivity of CB[7] toward AA residues in proteins. Complex formation between CB[7] and each AA was examined in soluti...
متن کاملA tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids.
There is evidence that tRNA bodies have evolved to reduce differences between aminoacyl-tRNAs in their affinity to EF-Tu. Here, we study the kinetics of incorporation of L-amino acids (AAs) Phe, Ala allyl-glycine (aG), methyl-serine (mS), and biotinyl-lysine (bK) using a tRNA(Ala)-based body (tRNA(AlaB)) with a high affinity for EF-Tu. Results are compared with previous data on the kinetics of ...
متن کاملSeed and vascular expression of a high-affinity transporter for cationic amino acids in Arabidopsis.
In most plants amino acids represent the major transport form for organic nitrogen. A sensitive selection system in yeast mutants has allowed identification of a previously unidentified amino acid transporter in Arabidopsis. AAT1 encodes a hydrophobic membrane protein with 14 membrane-spanning regions and shares homologies with the ecotropic murine leukemia virus receptor, a bifunctional protei...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 1975
ISSN: 0028-0836,1476-4687
DOI: 10.1038/253481a0